Many people on Ozempic or other GLP-1 medications experience digestive side effects like nausea, bloating, and constipation — but certain supplements may help support a smoother adjustment. This guide explains which digestive and liver-supporting ingredients are generally considered compatible with GLP-1 medications and how to use them safely.

This guide explains what to expect during the first days, weeks, and months on GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound. It covers common digestive and mental health side effects, how the body adapts over time, and strategies to support digestion, hydration, and liver health throughout the process.